Adrenal Hyperandrogenism in Children

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Adrenal function in children.

Attention has been drawn to the rarity of reports on Addison's disease in children by Greenberg (1958) and Szczepanska and Sapiecha (1959). The diagnosis can be difficult to make since features such as anorexia, recurrent dehydration and general debility are not specific for the condition (Talbot, Sobel, McArthur and Crawford, 1952). Often the diagnosis is made in retrospect or after the child ...

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Adrenal hyperandrogenism does not deteriorate insulin resistance and lipid profile in women with PCOS

OBJECTIVE The aim of this study was to investigate the impact of adrenal hyperandrogenism on insulin resistance and lipid profile in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS We studied 372 women with PCOS according to the NIH criteria. 232 age- and BMI-matched women served as controls in order to define adrenal hyperandrogenism (DHEA-S >95th percentile). Then, patient...

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Growth-restricted preterm newborns are predisposed to functional adrenal hyperandrogenism in adult life.

BACKGROUND The long-term effects of perinatal growth and corticosteroid exposure on adrenal steroid concentrations in adults born very preterm are uncertain. OBJECTIVES To examine the effect of birth weight, early postnatal growth, and pre- and postnatal corticosteroid administration on serum adrenal steroids in 19-year-old subjects born very preterm. DESIGN AND METHODS Subjects born before...

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Psychiatric characterization of children with genetic causes of hyperandrogenism.

OBJECTIVE Very little is known about the mental health status in children with genetic causes of hyperandrogenism. This study sought to characterize psychiatric morbidity in this group. DESIGN/METHODS Children (8-18 years) with the diagnosis of classic congenital adrenal hyperplasia (CAH) or familial male precocious puberty (FMPP) underwent a semi-structured psychiatric interview, the Kiddie ...

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ژورنال

عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism

سال: 1999

ISSN: 0021-972X,1945-7197

DOI: 10.1210/jcem.84.12.6284